The C957T polymorphism in the dopamine receptor D2 gene modulates domain-general category learning
نویسندگان
چکیده
Zilong Xie, W. Todd Maddox, John E. McGeary, and Bharath Chandrasekaran Department of Communication Sciences & Disorders, The University of Texas at Austin, Austin, Texas; Department of Psychology, The University of Texas at Austin, Austin, Texas; Division of Behavioral Genetics, Rhode Island Hospital, Providence, Rhode Island; Brown University, Providence, Rhode Island; and Psychologist, Providence Veterans Affairs Medical Center, Providence, Rhode Island
منابع مشابه
The C957T polymorphism in the dopamine receptor D₂ gene modulates domain-general category learning.
Adaptive learning from reward and punishment is vital for human survival. Striatal and frontal dopaminergic activities are associated with adaptive learning. For example, the C957T single nucleotide polymorphism of the dopamine receptor D2 (DRD2) gene alters striatal D2 receptor availability and affects individuals' adaptive learning ability. Specifically, individuals with the T/T genotype, whi...
متن کاملT polymorphism in the dopamine receptor D 2 ( DRD 2 ) gene modulates domain - general category learning ( Running head : DRD 2 , domain - general category learning )
Adaptive learning from reward and punishment is vital for human survival. Striatal and frontal dopaminergic activities are associated with adaptive learning. For example, the C957T single nucleotide polymorphism of the DRD2 gene alters striatal D2 receptor availability and affects individuals’ adaptive learning ability. Specifically, individuals with the T/T genotype, which is associated with h...
متن کاملAssociation study of three polymorphisms in the dopamine D2 receptor gene and schizophrenia in the Russian population.
Polymorphisms in the dopamine D2 receptor gene (DRD2) have repeatedly been associated with schizophrenia. Recently, the C957T polymorphism (rs6277), which alters mRNA stability and dopamine-induced upregulation of DRD2 expression in cell cultures and DRD2 mRNA translation in vitro, was tested for an association with the disease. Frequency of the C allele, corresponding to a normal wild-type lev...
متن کاملDepressive rumination and the C957T polymorphism of the DRD2 gene.
Depressed individuals who ruminate have difficulties learning from punishment and suppressing task-irrelevant information. The C957T polymorphism of the DRD2 gene, which affects functioning of D2 dopamine receptors (DRD2) that are expressed predominantly in the indirect pathway of the basal ganglia, has been found to influence suppression and punishment learning. Given these associations, we ex...
متن کاملDRD2 C957T polymorphism interacts with the COMT Val158Met polymorphism in human working memory ability.
The C957T polymorphism in the dopamine D2 receptor (DRD2) gene and the Val158Met polymorphism in the Catechol-O-Methyl-Transferase (COMT) gene affect dopamine transmission and have been found to be associated with schizophrenia. Since DRD2 in mice and the COMT gene in humans modulate working memory, we examined the relationship and possible interaction of both polymorphisms to working memory pe...
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